… that the (±)-cis-(6-ethyl-tetrahydropyran-2-yl)-formic acid (tetrahydropyran derivative) produces
potent antinociceptive effects in acute nociceptive and inflammatory pain in mice. These …

… and effect of (± )-cis-(6-ethyl-tetrahydropyran-2-yl) formic acid. … antinociceptive activity and
its pharmacological activity has … on the antinociceptive effects of morphine in mice. Methods …

… synthesis of (±)-cis-(6-ethyl-tetrahydropyran-2-yl) formic acid (2a), 6 and for the (−)-(S,S)-2b …
The antinociceptive activity of 2a was evaluated in mice on acetic acid-induced abdominal …

… Mice were tested according to Eddy and Leimback. The animals tail were placed on a water
… This substance developed a maximal effect increasing the antinociceptive activity in 40% …

… of (±)-cis-(6-ethyl-tetrahydropyran-2-yl) formic acid (1a) [5], and for the (-)–(S,S)–1b … The
antinociceptive activity of 1a was evaluated in mice on acetic acid-induced abdominal writhing, …

… to the (Æ) cis (6-ethyl-tetrahydropyran-2-yl) formic acid (1) using the … This new compound
presented a significant antinociceptive … Mice were tested according to Eddy and Leimback.The …

… treatment mice were tolerant to the analgesic effect of … effect was observed only after 7 days
of consecutive treatment. Nevertheless, mice retained an effect and the antinociceptive effect …

… That way, we performed in vitro evaluation for anticancer activity against cancer cell lines,
such as the … Other studies corroborate with our results, demonstrating increased activity of …

… )-cis,cis-6 [13,14] and recently the anti-hyperalgesic effect of is … (±)-cis-7 [16,17] presents
an analgesic effect in the same … from the acetic acid-induced abdominal writhes in mice to 6 = …

… the clinical effect of morphine, 6 and increases both the accumulation in the brain and the
antinociceptive effect of morphine in rats. … and antinociceptive effect of oxycodone in mice. …